Effect of calcium phosphate addition to alginate microspheres: Modulation of enzyme release kinetics and improvement of cell adhesion

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Barrias, CC (Autor) Outra; Ribeiro, CC (Autor) Outra; Rodrigues, D (Autor) Outra; Miranda, MCS (Autor) Outra; Mário Adolfo Barbosa (Autor) FEUP

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 5 Citações

Outras Informações

ID Authenticus: P-000-58G

Abstract (EN): In this study, the addition of calcium phosphate powders to an alginate matrix was evaluated as a strategy to modulate enzyme release-kinetics from alginate microspheres and, simultaneously, to improve cell adhesion to the polymer. Pre-adsorption of the enzyme to the ceramic powders resulted in a more adequate release pattern. The ratio of ceramic-to-polymer had a pronounced effect on osteoblast adhesion to microspheres. Cells were only able to spread on microspheres with the highest percentage of ceramic (0.4 w/w using a 1.5% w/v alginate solution).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4