Telomerase Activation in Hematological Malignancies

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2016

Autores

Ropio, J (Autor) Outra; Merlio, JP (Autor) Outra; Soares, P (Autor) FMUP; Chevret, E (Autor) Outra

Revista

Título: Genes

Vol. 7

Página Final: 61

ISSN: 2073-4425

Editora: MDPI

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 23 Citações

Outras Informações

ID Authenticus: P-00K-WHH

DOI: 10.3390/genes7090061

Abstract (EN): Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of telomerase activation and the associated hematologic malignancies.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13