CC chemokine receptor polymorphism CCR5 Delta 32 in Portuguese Behcet's disease patients

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Bettencourt, A (Autor) Outra; Leal, B (Autor) Outra; Carvalho, C (Autor) Outra; Oliveira, R (Autor) Outra; Martins Silva, AM (Autor) Outra; Vaz Patto, JV (Autor) Outra; Bastos, M (Autor) Outra; Costa, L (Autor) Outra; costa, pp (Autor) ICBAS; Vasconcelos, C (Autor) Outra; Correia, J (Autor) Outra; Silva, BM (Autor) Outra

Revista

Título: Clinical and Experimental Rheumatology

Vol. 32

Páginas: S72-S74

ISSN: 0392-856X

Editora: Pacini Editore SpA

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-009-V9M

Abstract (EN): Objective. To investigate whether CCR5 deletion is associated with susceptibility to Behcet's disease (BD) in a Portuguese population. Methods. A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5 Delta 32 polymorphisms was performed using polymerase chain reaction product sizing. Results. No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences. Conclusion. These results indicate that CCR5 Delta 32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3