Biological significance of cancer-associated sialyl-Tn antigen: Modulation of malignant phenotype in gastric carcinoma cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2007

Autores

Pinho, S (Autor) Outra; Marcos, NT (Autor) Outra; Ferreira, B (Autor) Outra; Carvalho, AS (Autor) Outra; Oliveira, MJ (Autor) Outra; Santos-Silva F (Autor) FMUP; Harduln Lepers, A (Autor) Outra; Celso Reis (Autor) FMUP

Revista

Título: Cancer Letters

Vol. 249

Páginas: 157-170

ISSN: 0304-3835

Editora: Elsevier

Indexação

ISI Web of Knowledge - 108 Citações

Scopus - 117 Citações

Outras Informações

ID Authenticus: P-004-A4G

DOI: 10.1016/j.canlet.2006.08.010

Abstract (EN): The activation of an abnormal glycosylation pathway in cancer cells leads to the formation of the sialyl-Tn antigen, blocking regular carbohydrate chain elongation. Sialyl-Tn antigen is rarely expressed in normal tissues but is aberrantly expressed in a variety of carcinomas, where it constitutes a marker of poor prognosis. Although the clinical significance of sialyl-Tn is well characterized, a functional role for this glycan and its contribution to cancer progression remain to be elucidated. This study evaluates the capability of sialyl-Tn to modify processes like cell cycle, apoptosis, actin cytoskeleton dynamics, adhesion and motility on ECM components, cell-cell aggregation and invasion. De-novo expression of sialyl-Tn leads to major morphological and cell behavior alterations in gastric carcinoma cells which were reverted by specific antibody blockage. Sialyl-Tn antigen is able to modulate a malignant phenotype inducing a more aggressive cell behavior, such as decreased cell-cell aggregation and increased ECM adhesion, migration and invasion.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14