Canine tumors: a spontaneous animal model of human carcinogenesis

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Pinho, SS (Autor) Outra; Carvalho, S (Autor) Outra; Cabral, J (Autor) Outra; Celso Reis (Autor) ICBAS; Gaertner, F (Autor) Outra

Revista

Título: Translational Research

Vol. 159

Páginas: 165-172

ISSN: 1931-5244

Editora: Elsevier

Indexação

ISI Web of Knowledge - 149 Citações

Scopus - 158 Citações

Outras Informações

ID Authenticus: P-002-CRP

DOI: 10.1016/j.trsl.2011.11.005

Abstract (EN): The enormous biologic complexity of human cancer has stimulated the development of more appropriate experimental models that could resemble in a natural and spontaneous manner the physiopathologic aspects of cancer biology. Companion animals have many desired characteristics that fill the gap between in vitro and in vivo studies, and these characteristics have proven to be important in understanding many complex molecular aspects of human cancer. Spontaneous tumors in dogs share a wide variety of epidemiologic, biologic, and clinical features with human cancer, which makes this animal model both attractive and underused in oncology research. In this review, we summarize the importance of naturally occurring canine tumors as valuable tools for studying numerous aspects of human cancer as well as the potential use of this animal model for the development of new cancer treatments. We address specifically the use of canine mammary tumors as an increasingly powerful model to study human breast cancer. (Translational Research 2012;159:165-172)

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8