Loss of Mitochondrial SDHB Expression: What is its Role in Diffuse Thyroid Lipomatosis?

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Lau, E (Autor) Outra; Freitas, P (Autor) FMUP; Costa, J (Autor) Outra; Batista, R (Autor) Outra; Maximo, V (Autor) FMUP; Coelho, R (Autor) Outra; Matos Lima, L (Autor) Outra; Eloy, C (Autor) Outra; Carvalho, Davide (Autor) FMUP

Revista

Título: Hormone and Metabolic Research

Vol. 47

Páginas: 165-167

ISSN: 0018-5043

Editora: Thieme

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 7 Citações

Outras Informações

ID Authenticus: P-00A-7XC

DOI: 10.1055/s-0034-1398559

Abstract (EN): Diffuse lipomatosis of the thyroid gland is a very rare disease, characterized by extensive infiltration of thyroid parenchyma by mature adipose tissue, usually not accompanied by amyloid fibrils deposition. The pathophysiology of adipose tissue infiltration in the thyroid gland remains unknown. We report a clinical case of a diffuse thyroid lipomatosis, whose immunohistochemical study of succinate dehydrogenase subunit B (SDHB) revealed loss of expression of this protein in the follicular or adipose cells. We detected the presence of a recently described SDHB gene large deletion. Loss of mitochondrial SDHB expression may have a key role in understanding the pathophysiology of thyrolipomatosis, by regulating status of lipid metabolism.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3