Thalidomide-induced acute cholestatic hepatitis: Case report and review of the literature

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Vilas Boas, F (Autor) Outra; Goncalves, R (Autor) Outra; Sobrinho Simoes, M (Autor) FMUP; Lopes, J (Autor) Outra; Macedo G (Autor) FMUP

Revista

Título: Gastroenterologia y Hepatologia

Vol. 35

Páginas: 560-566

ISSN: 0210-5705

Editora: Elsevier

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 11 Citações

Outras Informações

ID Authenticus: P-002-4XF

DOI: 10.1016/j.gastrohep.2012.05.007

Abstract (EN): Drug-induced liver injury (DILI) is a leading cause of liver failure and an important safety issue in drug development. Thalidomide is nowadays used for the treatment of several conditions including multiple myeloma (MM). Several adverse effects have been described but liver toxicity was seldom reported. We describe a case of thalidomide-induced hepatitis in a man treated for MM. The clinical setting and temporal association between the start of the drug and liver injury allowed the assumption of the causative role of thalidomide. As its clinical indications expand we wish to increase awareness of a new potential side effect of thalidomide. A short review on thalidomide-induced liver injury is also presented.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7