First-degree relatives of patients with early-onset gastric carcinoma show even at young ages a high prevalence of advanced OLGA/OLGIM stages and dysplasia

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Marcos Pinto, R (Autor) Outra; Carneiro F (Autor) FMUP; Mario Dinis Ribeiro (Autor) FMUP; Wen, X (Autor) Outra; Lopes, C (Autor) Outra; Figueiredo C (Autor) FMUP; Machado JC (Autor) FMUP; Ferreira, RM (Autor) Outra; Celso Reis (Autor) ICBAS; Ferreira, J (Autor) Outra; Pedroto, I (Autor) ICBAS; Areias JC (Autor) FMUP

Revista

Título: ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Vol. 35

Páginas: 1451-1459

ISSN: 0269-2813

Editora: John Wiley & Sons

Indexação

ISI Web of Knowledge - 53 Citações

Scopus - 64 Citações

Outras Informações

ID Authenticus: P-002-9RM

DOI: 10.1111/j.1365-2036.2012.05111.x

Abstract (EN): Background First-degree relatives (FDRs) of early-onset gastric carcinoma (EOGC) patients are at increased risk of cancer development. OLGA/OLGIM (Operative Link on Gastritis/Intestinal Metaplasia Assessment) classifications have been proposed for the identification of individuals at high risk of gastric cancer development. Aim To estimate the prevalence and severity of premalignant conditions and lesions in FDRs of EOGC patients. Methods A casecontrol study was conducted encompassing 103 FDRs of EOGC patients (cases) and 101 age- and gender-matched controls, all submitted to upper GI endoscopy and OLGA and OLGIM used for staging as well as modified versions with exclusion of the biopsies from incisura angularis in the analysis. Results Helicobacter pylori infection was present in 82% of cases (P = 0.001). Atrophy was present in 70% of cases (OLGA stages IIV). High-risk stages (IIIIV) were identified only in cases (19%) (P < 0.001). Dysplasia was diagnosed only in cases (n = 7, P = 0.007). The application of OLGIM, modified OLGA and modified OLGIM classifications led to downgrade of stages in comparison with the original OLGA classification (27%, 15% and 30% respectively). In all classification systems, dysplastic lesions clustered (86%) in high-risk stages. Conclusions FDRs of EOGC patients have, even at young ages, a high prevalence of H. pylori infection, high-risk OLGA and OLGIM stages and dysplasia. These patients should undergo accurate endoscopic observation with at least four biopsies in antrum and corpus to allow adequate staging and follow-up of premalignant conditions and lesions scored in high-risk stages, in accordance with international guidelines recently proposed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9