Pathogenesis of Helicobacter pylori Infection

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2009

Autores

Costa, AC (Autor) Outra; Figueiredo C (Autor) FMUP; Touati, E (Autor) Outra

Revista

Título: Helicobacter

Vol. 14 Nº 6

Páginas: 15-20

ISSN: 1083-4389

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 66 Citações

Scopus - 68 Citações

Outras Informações

ID Authenticus: P-003-G47

DOI: 10.1111/j.1523-5378.2009.00702.x

Abstract (EN): Helicobacter pylori induces chronic inflammation of the gastric mucosa, but only a proportion of infected individuals develop peptic ulcer disease or gastric carcinoma. Reasons underlying these observations include differences in bacterial pathogenicity as well as in host susceptibility. Numerous studies published in the last year provided new insight into H. pylori virulence factors, their interaction with the host and consequences in pathogenesis. These include the role of bacterial genetic diversity in host colonization and persistence, outer membrane proteins and modulation of adhesin expression, new aspects of VacA functions, and CagA and its phosphorylation-dependent and -independent cellular effects. This article will also review the recent novel findings on the interactions of H. pylori with diverse host epithelial signaling pathways and events involved in the initiation of carcinogenesis, including genetic instability and dysregulation of DNA repair.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6