Epithelial E- and P-cadherins: Role and clinical significance in cancer

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Joana Paredes (Autor) FMUP; Figueiredo, J (Autor) Outra; Albergaria, A (Autor) FMUP; Oliveira, P (Autor) Outra; Carvalho, J (Autor) Outra; Ribeiro, AS (Autor) Outra; Caldeira, J (Autor) Outra; Costa, AM (Autor) Outra; Simoes Correia, J (Autor) Outra; Oliveira, MJ (Autor) FCUP; Pinheiro, H (Autor) Outra; Pinho, SS (Autor) Outra; Mateus, R (Autor) Outra; Celso Reis (Autor) ICBAS; Marina Leite (Autor) Outra; Fernandes, MS (Autor) Outra; Fernando Schmitt (Autor) FMUP; Carneiro F (Autor) FMUP; Figueiredo C (Autor) FMUP; Oliveira, C (Autor) Outra; Seruca, R (Autor) FMUP

Revista

Título: Biochimica et Biophysica Acta - Reviews on Cancer

Vol. 1826

Páginas: 297-311

ISSN: 0304-419X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 169 Citações

Scopus - 183 Citações

Outras Informações

ID Authenticus: P-002-34Z

DOI: 10.1016/j.bbcan.2012.05.002

Abstract (EN): E-cadherin and P-cadherin are major contributors to cell-cell adhesion in epithelial tissues, playing pivotal roles in important morphogenetic and differentiation processes during development, and in maintaining integrity and homeostasis in adult tissues. It is now generally accepted that alterations in these two molecules are observed during tumour progression of most carcinomas. Genetic or epigenetic alterations in E- and P-cadherin-encoding genes (CDH1 and CDH3, respectively), or alterations in their proteins expression, often result in tissue disorder, cellular de-differentiation, increased invasiveness of tumour cells and ultimately in metastasis. In this review, we will discuss the major properties of E- and P-cadherin molecules, its regulation in normal tissue, and their alterations and role in cancer, with a specific focus on gastric and breast cancer models.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 15