Clinicopathological Significance of Immunoexpression of Claudin-1 and Claudin-7 in Feline Mammary Carcinomas

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Dias Pereira P (Autor) ICBAS; Flores AR (Autor) Outra; Rema A (Autor) ICBAS; Carvalho F (Autor) ICBAS; lopes, g (Autor) ICBAS; Augusto Faustino (Autor) ICBAS

Revista

Título: Journal of Comparative Pathology

Vol. 151

Páginas: 339-346

ISSN: 0021-9975

Editora: Elsevier

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00A-5QQ

DOI: 10.1016/j.jcpa.2014.07.006

Abstract (EN): Claudins (CLDNs) are tight junction proteins that have a role in regulating cell adhesion and polarity, paracellular permeability, proliferation and differentiation. Several immunohistochemical studies have shown reduced expression of CLDN-1 and CLDN-7 in human and canine mammary carcinomas, suggesting that these proteins may participate in mammary carcinogenesis, invasion and metastasis. The present study characterizes expression of CLDN-1 and CLDN-7 in feline mammary carcinomas (n = 52) and their metastases (n = 29). There was an inverse association between CLDN-7 expression and histological grade of tumour. Reduced expression of CLDN-7 was significantly associated with decreased tubule formation, high proliferative activity and metastasis. No significant associations were found between CLDN-1 expression and any of these features. Evaluation of expression of CLDN-7, but not CLDN-1, may therefore provide prognostic information, assisting in the diagnosis of a subgroup of aggressive feline mammary carcinomas that share some features with the recently described 'claudin-low' subgroup of human breast cancer.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8