The C677T polymorphism in MTHFR is not associated with migraine in Portugal

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Ferro, A (Autor) Outra; Castro, MJ (Autor) Outra; Carolina Lemos (Autor) Outra; Santos, M (Autor) Outra; Alda Sousa (Autor) ICBAS; Pereira Monteiro, J (Autor) Outra; Sequeiros, J (Autor) ICBAS; Maciel, P (Autor) Outra

Revista

Título: Disease Markers

Vol. 25

Páginas: 107-113

ISSN: 0278-0240

Editora: Hindawi

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 13 Citações

Outras Informações

ID Authenticus: P-004-31W

DOI: 10.1155/2008/178679

Abstract (EN): Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case-control study, we investigated the effect of the C677T polymorphism in MTHFR, as a genetic risk factor for migraine, in the Portuguese population. We observed that, overall, there was no significant difference in the frequencies of MTHFR C677T genotypes or of the T-allele among the Portuguese migraineurs when compared to controls. There was also no association of migraine with aura with MTHFR genotypes or with the T-allele, in contrast with previous studies. Regarding the risk of the T-allele homozygote carriers, there was an equal probability to develop migraine with aura over migraine without aura in our patients. Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7