HEMOCHROMATOSIS AS A WINDOW INTO THE STUDY OF THE IMMUNOLOGICAL SYSTEM - A NOVEL CORRELATION BETWEEN CD8+ LYMPHOCYTES AND IRON OVERLOAD

• Tipo: Artigo em Revista Científica Internacional
• Data: 1994

Autores

Graca Porto (Autor) ICBAS; REIMAO, R (Autor) Outra; GONCALVES, C (Autor) Outra; Corália Vicente (Autor) ICBAS; JUSTICA, B (Autor) Outra; DESOUSA, M (Autor) Outra

Revista

Título: European Journal of Haematology

Vol. 52

Páginas: 283-290

ISSN: 0902-4441

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 59 Citações

Scopus - 55 Citações

Outras Informações

ID Authenticus: P-001-K3G

Abstract (EN): In the present study we report a serial investigation of the numbers of the peripheral blood cells - erythrocytes, polymorphonuclear neutrophils, total lymphocytes, T-lymphocyte subpopulations (CD2, CD4, CD8), B lymphocytes and monocytes - in a group of 21 patients with haemochromatosis during the time of intensive phlebotomy treatment, i.e., from iron overload until the onset of iron deficiency. A remarkable individual stability of all blood cell populations studied was found in all patients. Patients differed in their relative proportions of CD4(+) and CD8(+). Each individual's CD4/CD8 ratio, as well as the absolute numbers, remained unaffected with time, confirming the existence of a strict homeostatic regulation of the relative numbers of the two major peripheral T lymphocytes. A significant positive correlation between CD4/CD8 ratios and the amount of iron mobilised by phlebotomy was found during this study. A novel correlation between the relative proportions of CD4(+) and CD8(+) cells and iron overload is confirmed by the follow-up of iron re-entry in the serum transferrin pool in the treated patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8