Relative impact of HLA phenotype and CD4-CD8 ratios on the clinical expression of hemochromatosis

• Tipo: Artigo em Revista Científica Internacional
• Data: 1997

Autores

Graca Porto (Autor) ICBAS; Corália Vicente (Autor) ICBAS; Teixeira, MA (Autor) Outra; Martins, O (Autor) Outra; Cabeda, JM (Autor) Outra; Lacerda, R (Autor) Outra; Goncalves, C (Autor) Outra; Fraga, J (Autor) Outra; Macedo G (Autor) Outra; silva, bm (Autor) ICBAS; Alves, H (Autor) Outra; Justica, B (Autor) Outra; deSousa, M (Autor) Outra

Revista

Título: Hepatology

Vol. 25

Páginas: 397-402

ISSN: 0270-9139

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 66 Citações

Scopus - 67 Citações

Outras Informações

ID Authenticus: P-001-C0W

Abstract (EN): Hemochromatosis is a hereditary iron-overload disease linked to HLA. The clinical expression of hemochromatosis is influenced by sex and age, However, other factors must account for the notorious heterogeneity of expression of the disease independent of sex, age, and HLA phenotype. The present study attempts to clarify some of these additional factors based on exhaustive statistical analysis of data collected from 43 selected patients with hemochromatosis, The statistical analysis focused on three groups of variables: the first group included variables reflecting the clinical expression of the disease; the second group represented the biochemical and hematological values at the time of diagnosis; and the third group consisted of the independent variables sex, age, HLA phenotype, and T-cell subset profile, i.e., the percentages and total numbers of CD4+ and CD8+ cells and the CD4-CD8 ratios. The results show that the relative expansion of the two main T-cell subsets, in the context of the HLA phenotype, correlates significantly with the clinical expression of hemochromatosis and the severity of iron overload. The present findings substantiate further the postulate that T cells have a role in the regulation of iron metabolism.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6