tef: a mutation that causes telomere fusion and severe genome rearrangements in Drosophila melanogaster

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Queiroz Machado, J (Autor) Outra; Perdigao, J (Autor) Outra; Simoes Carvalho, P (Autor) Outra; Herrmann, S (Autor) Outra; Sunkel, CE (Autor) ICBAS

Revista

Título: Chromosoma

Vol. 110

Páginas: 10-23

ISSN: 0009-5915

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 20 Citações

Scopus - 21 Citações

Outras Informações

ID Authenticus: P-000-VWV

DOI: 10.1007/s004120000116

Abstract (EN): Telomeres are the stable ends of linear chromosomes in eukaryotes. These complex protein-nucleic acid structures are essential to maintain genomic stability and the integrity of linear chromosomes. We identified a new mutation in Drosophila that causes a high frequency of end-to-end fusions of chromosomes during mitosis and meiosis. Linear chromosomal ends appear to be essential for fusions to take place. These fusions do not resolve, leading to cycles of chromosomal breakage and rejoining and severe genome rearrangements. The gene is essential for normal cell proliferation and mutant tissue shows significant apoptosis. Our analysis suggests that the function encoded by the mutant gene is required to protect the linear ends of chromosomes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14