Overall survival in women with breast cancer: The influence of Pepsinogen C gene polymorphism

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Pinto Correia, AL (Autor) Outra; Pinto, D (Autor) Outra; Pereira, D (Autor) Outra; Rodrigues, H (Autor) Outra; de Sousa, JA (Autor) Outra; Sousa, H (Autor) Outra; Sousa, B (Autor) Outra; Sousa, S (Autor) Outra; Lopes, C (Autor) ICBAS; Rui Medeiros (Autor) ICBAS

Revista

Título: DNA and Cell Biology

Vol. 27

Páginas: 333-336

ISSN: 1044-5498

Editora: Mary Ann Liebert

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-003-YQ9

DOI: 10.1089/dna.2007.0713

Abstract (EN): We aimed to study the role of an insertion/deletion polymorphism in the Pepsinogen C (PGC) gene in the clinical outcome of 172 breast cancer patients. The six polymorphic alleles were amplified using PCR. Our results indicate that patients carrying the allele 6 present a higher 5-year survival mean (83.4% of 6 allele carriers were alive at 5 years vs. only 68.6% of noncarriers, p = 0.001), suggesting a role for this polymorphism in the outcome of breast cancer patients. We hypothesize that PGC polymorphism can be a predictive biomarker in breast cancer, contributing to an individual profile of great interest in clinical oncology.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4