Molecular interactions between human cytochrome P450 1A2 and flavone derivatives

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

da Fonseca, R (Autor) Outra; Melo, A (Autor) FCUP; Iori, F (Autor) Outra; Menziani, C (Autor) Outra; Ramos, MJ (Autor) FCUP

Revista

Título: Medicinal Chemistry

Vol. 2

Páginas: 401-406

ISSN: 1573-4064

Editora: Bentham Science

Indexação

ISI Web of Knowledge

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-007-FX3

DOI: 10.2174/157340606777723988

Abstract (EN): Activation by human cytochrome P450 1A2 (hCYP1A2) of heterocyclic amines is assumed to trigger of a number of carcinogenic processes. In this work, a group of natural inhibitors of human cytochrome P450 1A2 reported in literature has been theoretically analysed. These consist of flavone hydroxylated derivatives, natural compounds that exist in plants and associated products. Different theoretical/computational tools were used to describe the specific molecular interactions between these compounds and hCYP1A2. Based on this analysis, a method is proposed for helping the selection of specific molecular features that enhance protein-inhibitor interaction. © 2006 Bentham Science Publishers Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica