The impact of GGH -401C > T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Ines Hilario Silva (Autor) Outra; Cristina Nogueira Silva (Autor) Outra; Tiago Figueiredo (Autor) Outra; Liliana Lombo (Autor) Outra; Ilda Faustino (Autor) Outra; Raquel Catarino (Autor) Outra; Augusto Nogueira (Autor) Outra; Deolinda Pereira (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: Gene

Vol. 512

Páginas: 247-250

ISSN: 0378-1119

Editora: Elsevier

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 7 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências da terra e ciências do ambiente

Outras Informações

ID Authenticus: P-002-19J

DOI: 10.1016/j.gene.2012.10.038

Abstract (EN): Aims: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C > T polymorphism in treatment response in cervical cancer. Methods: We retrospectively reviewed the clinical data of 167 patients with bulky cervical cancer submitted to cisplatin-based chemoradiotherapy. The genotypes of GGH -401C > T SNP were determined by real-time PCR and statistical analysis was performed by chi(2) test and survival analysis. Results: The genotypes of GGH-401C > T were significantly associated with the response to platinum-based chemoradiotherapy. Treatment response was higher in patients carrying the CC genotype, who presented a significant increased chance of treatment response (survival time in months/genotype: 91 for CC Vs 72 for CT/TT; p = 0.035, log rank test). A Cox regression analysis accordingly showed that the presence of the T allele was significantly linked to a worse treatment response (HR = 3.036; CI 95% 1.032-8.934, p = 0.044). Conclusions: The results of our study suggested the potential interest of GGH -401C > T as a predictive factor of the outcome of cervical carcinoma treated with cisplatin-based chemoradiotherapy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4