Cervical cancer and CYP2E1 polymorphisms: implications for molecular epidemiology

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Ferreira, PM (Autor) Outra; Catarino, R (Autor) Outra; Pereira, D (Autor) Outra; Matos, A (Autor) Outra; Pinto, D (Autor) Outra; Coelho, A (Autor) Outra; Lopes, C (Autor) ICBAS; Medeiros, R (Autor) ICBAS

Revista

Título: European Journal of Clinical Pharmacology

Vol. 62

Páginas: 15-21

ISSN: 0031-6970

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 12 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-004-PMJ

DOI: 10.1007/s00228-005-0066-y

Abstract (EN): Introduction: Besides human papillomavirus (HPV) infection, several cofactors are considered important for the development of cervical cancer (CC). Among these, tobacco smoke, other sexually transmitted diseases, inflammation and nutritional factors have been intensively described. CYP2E1 polymorphisms have been associated with the metabolization of several carcinogens, some of them considered risk factors for CC development, such as tobacco smoke. The aim of this study was to evaluate the role of CYP2E1 polymorphisms in the susceptibility to cervical cancer in a Portuguese population. Patients and methods: The genotypic analysis was performed with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology, using peripheral blood samples of 454 individuals: 122 presented invasive squamous cell carcinoma (ICC), 59 presented squamous intraepithelial lesions (SIL), and the control population was composed of 274 healthy individuals. Results: Concerning the DraI polymorphism, we observed a decreased risk for the development of squamous cervical lesions in the presence of the C allele [odds ratio (OR)=0.600; 0.378<OR<0.952; p=0.029]. In the stratification of the analysis according to the mean age, we observed an increased risk for the development of SIL, for women older than 39 years of age, in the presence of the D allele (OR=0.087; 0.012<OR<0.651; p=0.003). Regarding the RsaI polymorphism, we did not find any significant differences. Conclusion: The decreased risk observed for the development of SIL and not ICC in the presence of the D allele may indicate that CYP2E1 interferes with the initial steps of the carcinogenic process, probably due to its involvement in the action of immunological mediators, expressed during cervical inflammation. These aspects may help to define new therapeutic strategies for chemoprevention.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7