Supramolecular nanoscale assemblies for cancer diagnosis and therapy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Sílvia Castro Coelho (Autor) FEUP; Maria do Carmo Pereira (Autor) FEUP; Asta Juzeniene (Autor) Outra; Petras Juzenas (Autor) Outra; Manuel A. N. Coelho (Autor) FEUP

Revista

Título: Journal of Controlled Release

Vol. 213

Páginas: 152-167

ISSN: 0168-3659

Editora: Elsevier

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 21 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Projetos Associados

NanoEFEct - Nanoparticle enhanced molecular Fluorescence-Endoscopy for detection of early stage colorectal adenocarcinoma

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

LEPAE/CEFT - RL2 - (Bio) Chemical Engineering: Multi-Scale Approaches for Sustainable Environment and Health

Outras Informações

ID Authenticus: P-00G-E79

DOI: 10.1016/j.jconrel.2015.06.034

Abstract (EN): Nanocarriers based on polymers, metals and lipids have been extensively developed for cancer therapy and diagnosis due to their ability to enhance drug accumulation in cancer cells and decrease undesired drug toxicity in healthy tissues. Overcoming multidrug resistance by designing proper drug nanocarriers will improve outcome of existing oncologic treatments such as chemotherapy and radiotherapy. In this article the relation between physicochemical properties and capacity of a nanosystem to deliver therapeutic agents into pathological sites is discussed. Most promising examples of drug delivery systems are reviewed, and, in particular, the design of a carbohydrate based matrix with entrapped gold nanoparticles is highlighted.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 16