Transthyretin is involved in depression-like behaviour and exploratory activity

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Sousa, JC (Autor) Outra; Grandela, C (Autor) Outra; Fernandez Ruiz, J (Autor) Outra; de Miguel, R (Autor) Outra; de Sousa, L (Autor) ICBAS; Magalhaes, AI (Autor) Outra; Saraiva, MJ (Autor) ICBAS; Sousa, N (Autor) Outra; Palha, JA (Autor) Outra

Revista

Título: Journal of Neurochemistry

Vol. 88

Páginas: 1052-1058

ISSN: 0022-3042

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 99 Citações

Scopus - 106 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-000-BET

DOI: 10.1046/j.1471-4159.2003.02309.x

Abstract (EN): Transthyretin (TTR), the major transporter of thyroid hormones and vitamin A in cerebrospinal fluid (CSF), binds the Alzheimer beta-peptide and thus might confer protection against neurodegeneration. In addition, altered TTR levels have been described in the CSF of patients with psychiatric disorders, yet its function in the CNS is far from understood. To determine the role of TTR in behaviour we evaluated the performance of TTR-null mice in standardized tasks described to assess depression, exploratory activity and anxiety. We show that the absence of TTR is associated with increased exploratory activity and reduced signs of depressive-like behaviour. In order to investigate the mechanism underlying these alterations, we measured the levels of cathecolamines. We found that the levels of noradrenaline were significantly increased in the limbic forebrain of TTR-null mice. This report represents the first clear indication that TTR plays a role in behaviour, probably by modulation of the noradrenergic system.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7