Uncovering novel 3-hydroxy-4-pyridinone metal ion complexes with potential anti-inflammatory properties

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Chisté, RC (Autor) Outra; Ribeiro, D (Autor) Outra; Freitas, M (Autor) Outra; Leite, A (Autor) Outra; Moniz, T (Autor) Outra; Maria Rangel (Autor) ICBAS; Fernandes, E (Autor) FFUP

Revista

Título: Journal of Inorganic Biochemistry

Vol. 155

Páginas: 9-16

ISSN: 0162-0134

Editora: Elsevier

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 5 Citações

Outras Informações

ID Authenticus: P-00G-WRB

DOI: 10.1016/j.jinorgbio.2015.11.009

Abstract (EN): Ligands of the 3-hydroxy-4-pyridinone (3,4-HPO) type, with one (Hmpp) or two methyl groups (Hdmpp), have been reported to possess biomedical, chemical and analytical applications. In this first screening study aiming to uncover new promising agents to mitigate the oxidative damage highly present in several metabolic disorders, such as diabetes mellitus, we assessed the potential of twelve 3,4-HPO metal ion complexes to modulate oxidative burst in human neutrophils. Metal ion 3,4-HPO complexes of Ni, Fe, V, Co, Cu and Zn were synthesized and tested up to 15 mu M. Among all the compounds, [Cu(mpp)(2)] and [Cu(dmpp)(2)] exhibited the highest scavenging capacity against superoxide radical (O-2(center dot-)) (IC50 = 0.36 +/- 0.07 and 0.30 +/- 0.06 M, respectively) and against hypochlorous acid (HOCl) (IC50 = 0.6 +/- 0.3 and 0.4 +/- 0.1 mu M, respectively). In the particular case of O-2(center dot-), [Fe(mpp)(3)] and [Fe(dmpp)(3)] (both at 15 mu M) presented 35% and 22% of inhibition, respectively, while all the other compounds were neither able to scavenge O-2(center dot-) nor stimulate its production. Regarding the scavenging capacity against hydrogen peroxide (H2O2), all the compounds showed low efficiency (from 6-39%). Finally, with exception of [VO(mpp)(2)] and [VO(dmpp)(2)], all compounds exhibited scavenging activity against HOCl (39-81%) and the most efficient compounds were Cu(II) and Zn(II) complexes. Thus, these preliminary results uncover promising new metal ion complexes, inhibitors of neutrophil's oxidative burst, with potential anti-inflammatory properties, which may be seen as an useful strategy for further studies in the treatment of a number of diseases where oxidative damage is a serious issue.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8