Comparative study between the viscoelastic behaviors of different lipid nanoparticle formulations

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Souto, EB (Autor) Outra; Wissing, SA (Autor) Outra; Barbosa, CM (Autor) FFUP; Muller, RH (Autor) Outra

Revista

Título: Journal of Cosmetic Science

Vol. 55

Páginas: 463-471

ISSN: 1525-7886

Editora: Society of Cosmetic Chemists

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 35 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-000-8SG

DOI: 10.1111/j.1467-2494.2004.00252_4.x

Abstract (EN): Application of drug substances to the skin for systemic absorption or action in a particular layer of the skin is a rather old approach. However, over the last years it has received much more attention, as a consequence of the development of new membrane-moderated and matrix reservoir devices. As new reservoir systems, solid lipid nanoparticles (SLN(TM)) and nanostructured lipid carriers (NLC(TM)) have been successfully tested for dermal application of different physicochemical substances. The knowledge obtained from theological investigations of these systems may be highly Useful for the characterization of the newly developed topical formulation. In the present study, an oscillation frequency sweep test was used for the evaluation of storage modulus (G'), loss modulus (G"), and complex viscosity (eta*) of twelve different SLN and NLC formulations, over a frequency range from 0 to 10 Hz. The lipiclic aqueous dispersions were prepared using three different solid lipids (Softisan(R)138, Compritol(R)888, and stearyl alcohol) as matrix material. Miglyol(R)812, tocopherol, sunflower oil, and long-chain triacylglycerols were the chosen liquid lipids for NLC preparation. The objective of the present work was to investigate the effect of these different liquid lipids on the theological properties of aqueous dispersions of NLC as model systems. It was found that the liquid oil component of the formulation has a strong influence on the viscoelastic parameters, which are dependent on the particle size, zeta potential, and crystallinity of the lipid particles, as well as on the solid lipid used.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9