Losartan and atenolol on hypertension induced by adenosine receptor blockade

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

Morato, M (Autor) FFUP; Sousa, T (Autor) Outra; Guimaraes, S (Autor) Outra; Moura, D (Autor) Outra; Albino Teixeira, A (Autor) FMUP

Revista

Título: Autonomic and Autacoid Pharmacology

Vol. 23

Páginas: 133-140

ISSN: 1474-8665

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge

Scopus - 6 Citações

Outras Informações

ID Authenticus: P-007-BD0

DOI: 10.1046/j.1474-8673.2003.00287.x

Abstract (EN): 1 The prolonged infusion of 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), a non-selective antagonist of adenosine receptors, induces hypertension, an increase in plasma renin activity and morphological cardiovascular changes. 2 The aim of this work was to evaluate the effects of losartan, a selective AT1 receptor antagonist, and atenolol, a ß-adrenoceptor antagonist, on DPSPX-induced hypertension. 3 Male Wistar rats (250-300 g, n = 4-6) were treated for 1 or 4 weeks with: saline i.p.; DPSPX (90 ¿g kg -1 h-1) i.p.; losartan (15 mg kg-1 day -1) p.o.; atenolol (25 mg kg-1 day-1) p.o.; DPSPX (90 ¿g kg-1 h-1) i.p. + losartan (15 mg kg -1 day-1) p.o.; DPSPX (90 ¿g kg-1 h -1) i.p. + atenolol (25 mg kg-1 day-1) p.o. Blood pressure was measured by the 'tail-cuff' method in conscious animals. Fragments of the mesenteric and tail arteries were processed for morphological study and the mean diameter of the vascular smooth muscle cells was determined. 4 DPSPX increased blood pressure. Losartan and atenolol prevented this rise but had no effect on blood pressure of control rats. DPSPX-treated groups showed hypertrophy of the vascular smooth muscle cells and proliferation of subintimal cells. Losartan but not atenolol prevented these changes. Losartan had no effect on the vascular morphology of control rats, while treatment with atenolol for 4 weeks induced hypertrophy of the vascular smooth muscle cells. 5 Both losartan and atenolol counteract the development of DPSPX-induced hypertension but only losartan prevents the alterations in vascular morphology.

Idioma: Inglês

Tipo (Avaliação Docente): Científica