In vitro mineralisation of human bone marrow cells cultured on Bonelike (R)

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Maria Adelina Costa (Autor) ICBAS; Manuel Gutierres (Autor) FMUP; L. Almeida (Autor) Outra; Maria Ascensão Lopes (Autor) FEUP; José Domingos Santos (Autor) FEUP; Maria Helena Fernandes (Autor) FMDUP

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: BIOCERAMICS, VOL 16

Vol. 254-2

Páginas: 821-824

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 9 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

Outras Informações

ID Authenticus: P-000-CBM

DOI: 10.4028/www.scientific.net/kem.254-256.821

Abstract (EN): Bonelike(R) is a CaO-P2O5 based glass-reinforced hydroxyapatite (HA) designed to mimic the inorganic composition of the bone tissue. This work evaluates the response of human bone marrow cells to Bonelike(R) concerning cell proliferation and osteoblast differentiation. HA was used as control material. Results showed that Bonelike(R) allowed the proliferation of bone marrow cells and their complete differentiation, as evidenced by the formation of cell-mediated mineralisation. In comparison with HA, Bonelike(R) had a positive effect on the expression of alkaline phosphatase and also on the formation of a mineralised matrix, two osteoblast markers.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4