Fluorinated beta-sheet breaker peptides

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Joana A. Loureiro (Autor) FEUP; Rosa Crespo (Autor) FEUP; Hans Börner (Autor) Outra; Pedro M. Martins (Autor) ICBAS; Fernando A. Rocha (Autor) FEUP; Manuel Coelho (Autor) FEUP; M. Carmo Pereira (Autor) FEUP; Sandra Rocha (Autor) Outra

Revista

Título: Journal of Materials Chemistry B

Vol. 2 Nº 16

Páginas: 2259-2264

ISSN: 2050-7518

Editora: Royal Society of Chemistry

Indexação

ISI Web of Knowledge - 24 Citações

ISI Web of Science

Scopus - 34 Citações

Classificação Científica

CORDIS: Ciências Tecnológicas

FOS: Ciências da engenharia e tecnologias

Projetos Associados

Referência: PTDC/QUI-BIQ/102827/2008 - Concepção de péptidos fluorados para inibição da agregação do péptido beta-amilóide e avaliação da sua actividade biológica

Outras Informações

ID Authenticus: P-009-ASR

DOI: 10.1039/c3tb21483d

Abstract (EN): The aggregation of amyloid-beta peptide (Ab) has been linked to the formation of neuritic plaques, which are pathological hallmarks of Alzheimer's disease. We synthesized peptides containing fluorinated amino acids and studied their effect on the Ab aggregation. The peptides were based on the sequence LVFFD, in which valine was substituted by either 4,4,4-trifluorovaline or 4-fluoroproline, or the phenylalanine at position 3 was replaced by 3,4,5-trifluorophenylalanine. Our results demonstrate that fluorination of the hydrophobic residue valine or phenylalanine is effective in preventing the Ab aggregation. This study opens up the possibility of using new sequences based on fluorinated amino acids to inhibit the amyloid- fibril formation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6