Flavonoids Inhibit COX-1 and COX-2 Enzymes and Cytokine/Chemokine Production in Human Whole Blood

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Daniela Ribeiro (Autor) Outra; Marisa Freitas (Autor) Outra; Sara M Tome (Autor) Outra; Artur M S Silva (Autor) Outra; Stefan Laufer (Autor) Outra; Jose L F C Lima (Autor) Outra; Eduarda Fernandes (Autor) FFUP

Revista

Título: Inflammation

Vol. 38

Páginas: 858-870

ISSN: 0360-3997

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 26 Citações

Scopus - 51 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-00G-271

DOI: 10.1007/s10753-014-9995-x

Abstract (EN): Cyclooxygenase 2 (COX-2) and the production of cytokines/chemokines are important targets for the modulation of the inflammatory response. Although a large variety of inhibitors of these pathways have been commercialized, some of those inhibitors present severe side effects, governing the search for new molecules, as alternative anti-inflammatory agents. This study was undertaken to study an hitherto not evaluated group of flavonoids, concerning its capacity to inhibit COX-1 and COX-2 enzymes, as well as to inhibit the production of the cytokines and a chemokine, in a complex matrix involved in the systemic inflammatory process, the blood, aiming the establishment of a structure-activity relationship. The results obtained reveal promising flavonoids for the modulation of the inflammatory process, namely the ones presenting a catechol group in B ring, as some flavonoids were able to simultaneously inhibit the production of inflammatory prostaglandin E-2 and pro-inflammatory cytokines.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13