Glycaemic profile changes by highly active antiretroviral therapy in human immunodeficiency virus-infected patients

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Duro, M (Autor) Outra; Rebelo, I (Autor) FFUP; Barreira, S (Autor) Outra; Sarmento Castro, R (Autor) Outra; Medeiros, R (Autor) ICBAS; Almeida, C (Autor) Outra

Revista

Título: INTERNATIONAL JOURNAL OF STD & AIDS

Vol. 26

Páginas: 796-802

ISSN: 0956-4624

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 6 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-00G-NWF

DOI: 10.1177/0956462414554814

Abstract (EN): To study dysglycaemia in human immunodeficiency virus (HIV)-infected patients we conducted a retrospective cohort study of the glucose profile in HIV-infected patients. The fasting blood glucose was analysed taking into consideration conventional risk factors as well as HIV infection and highly active antiretroviral therapy (HAART). One hundred seventy-three cases were selected for this study. Five risk factors had significant effects (p< 0.05) on glucose levels: age, body mass index (BMI), hepatitis C virus/hepatitis B virus (HCV/HBV) co-infection, viral load (VL), and CD4(+) T-lymphocyte count. Fasting blood glucose levels increased with age (0.59 mg/dL/year), decreased with the VL (-4.1 x 10(-6) mg/dL/number of viral RNA copies) and the CD4(+) T-lymphocyte count (-0.016 mg/dL/cell count). Furthermore, obese patients and those co-infected with HCV/HBV were more prone to develop dysglycaemia having, on average, 15.4 mg/dL and 13.8 mg/dL higher levels, respectively, of fasting blood glucose. Despite an increase of 1.0% and 8.4% in the glucose levels noticed among HIV patients treated with non-nucleotide inhibitors of reverse transcriptase and protease inhibitors, respectively, HAART did not prove to be a significant predictor of fasting glucose levels as well as lipodystrophy and male gender. Age, BMI, HCV/HBV co-infection and HIV-related (VL and CD4(+) T-lymphocyte count) factors seem to be the most influential on fasting blood glucose levels in HIV-infected individuals.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7