Modulation of mammalian apoptotic pathways by intracellular protozoan parasites

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Rodrigues, V (Autor) Outra; Cordeiro da Silva, A (Autor) FFUP; Laforge, M (Autor) Outra; Ouaissi, A (Autor) Outra; Silvestre, R (Autor) Outra; Estaquier, J (Autor) Outra

Revista

Título: Cellular Microbiology

Vol. 14

Páginas: 325-333

ISSN: 1462-5814

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 14 Citações

Scopus - 18 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-002-CS2

DOI: 10.1111/j.1462-5822.2011.01737.x

Abstract (EN): During intracellular parasitic infections, pathogens and host cells take part in a complex web of events that are crucial for the outcome of the infection. Modulation of host cell apoptosis by pathogens attracted the attention of scientists during the last decade. Apoptosis is an efficient mechanism used by the host to control infection and limit pathogen multiplication and dissemination. In order to ensure completion of their complex life cycles and to guarantee transmission between different hosts, intracellular parasites have developed mechanisms to block apoptosis and sustain the viability of their host cells. Here, we review how some of the most prominent intracellular protozoan parasites modulate the main mammalian apoptotic pathways by emphasizing the advances from the last decade, which have begun to dissect this dynamic and complex interaction.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9