Proinflammatory Environment Dictates the IL-17-Producing Capacity of Human Invariant NKT Cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Lucia Moreira Teixeira (Autor) Outra; Mariana Resende (Autor) Outra; Maryaline Coffre (Autor) Outra; Odile Devergne (Autor) Outra; Jean Philippe Herbeuval (Autor) Outra; Olivier Hermine (Autor) Outra; Elke Schneider (Autor) Outra; Lars Rogge (Autor) Outra; Frank M Ruemmele (Autor) Outra; Michel Dy (Autor) Outra; Anabela Cordeiro da Silva (Autor) FFUP; Maria C Leite de Moraes (Autor) Outra

Revista

Título: Journal of Immunology

Vol. 186 Nº 10

Páginas: 5758-5765

ISSN: 0022-1767

Editora: American Association of Immunologists

Indexação

ISI Web of Knowledge - 55 Citações

Scopus - 73 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-002-RFK

DOI: 10.4049/jimmunol.1003043

Abstract (EN): CD1d-reactive invariant NKT (iNKT) cells have been implicated in a number of experimental models of human pathologies. Given the scope of their immunoregulatory activities mediated through distinct cytokine patterns, it has been proposed that this functional diversity originates from distinct iNKT subpopulations. In this study, we report that human CD161(+) iNKT cells are intrinsically endowed with the capacity to generate IL-17, but require TGF-beta, IL-1 beta, and IL-23 to carry out this potential. IL-17-producing iNKT cells are already present in cord blood but, in contrast to peripheral blood iNKT cells, they cannot generate IFN-gamma. These IL-17 producers respond to aryl hydrocarbon receptor stimulation and express IL-23 receptor and retinoic acid-related orphan receptor C, similar to conventional T helper 17 cells, from which they differ by their restricted ability to coproduce IL-22. In conclusion, IL-17 production by human iNKT cells depends on two critical parameters, namely an intrinsic program and a proinflammatory environment. The Journal of Immunology, 2011, 186: 5758-5765.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8