Sensitive sequential injection determination of naproxen based on interaction with beta-cyclodextrin

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Zisiou, EP (Autor) Outra; Pinto, PCAG (Autor) Outra; Saraiva, MLMFS (Autor) FFUP; Christophe Siquet (Autor) FEUP; Lima, JLFC (Autor) FFUP

Revista

Título: Talanta

Vol. 68

Páginas: 226-230

ISSN: 0039-9140

Editora: Elsevier

Indexação

ISI Web of Knowledge - 16 Citações

Scopus - 18 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-000-01S

DOI: 10.1016/j.talanta.2005.07.005

Abstract (EN): A sensitive sequential injection analysis (SIA) methodology for the fluorimetric determination of naproxen is proposed. The developed automatic analytical procedure is based on the complexation of naproxen with beta-cyclodextrin (beta-CD) yielding an enhanced fluorimetric signal (lambda(ex) = 280 nm, lambda(em) = 356 nm). Linear calibration plots were obtained for naproxen concentrations up to 1 x 10(-5) mol l(-1). The developed methodology exhibited a good precision, with a R.S.D. < 2.1 % (n = 15). The detection limit of the determination was 1.9 x 10(-7) mol l(-1) with a sampling rate of about 70 h(-1). The automatic method was applied to the determination of naproxen in pharmaceutical formulations. The obtained results were compared with those furnished by the reference procedure and the relative deviations were lower than 3.6%. No interference was found from the excipients usually used in solid pharmaceutical formulations.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5