Enantioselective biodegradation of fluoxetine by the bacterial strain Labrys portucalensis F11

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Irina S. Moreira (Autor) Outra; Ana R. Ribeiro (Autor) FEUP; Carlos M. Afonso (Autor) FFUP; M E Tiritan (Autor) FFUP; Paula M. L. Castro (Autor) Outra

Revista

Título: Chemosphere

Vol. 111

Páginas: 103-111

ISSN: 0045-6535

Editora: Elsevier

Indexação

ISI Web of Knowledge - 46 Citações

Scopus - 52 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências da terra e ciências do ambiente

Outras Informações

ID Authenticus: P-009-PZD

DOI: 10.1016/j.chemosphere.2014.03.022

Abstract (EN): Fluoxetine (FLX) is a chiral fluorinated pharmaceutical indicated mainly for the treatment of depression and is one of the most dispensed drugs in the world. There is clear evidence of environmental contamination with this drug and its active metabolite norfluoxetine (NFLX). In this study the enantioselective biodegradation of racemic FIX and of its enantiomers by Labrys portucalensis strain F11 was assessed. When 2 mu M of racemic FLX was supplemented as sole carbon source, complete removal of both enantiomers, with stoichiometric liberation of fluoride, was achieved in 30 d. For racemic FIX concentration of 4 and 9 mu M, partial degradation of the enantiomers was obtained. In the presence of acetate as an additional carbon source, at 4, 9 and 21 mu M of racemic FLX and at 25 mu M of racemic FIX, (S)-FLX or (R)-FLX, complete degradation of the two enantiomers occurred. At higher concentrations of 45 and 89 mu M of racemic FLX, partial degradation was achieved. Preferential degradation of the (R)-enantiomer was observed in all experiments. To our knowledge, this is the first time that enantioselective biodegradation of FIX by a single bacterium is reported.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9