Bioactive Friedolanostanes and 11(10-8)-Abeolanostanes from the Bark of Garcinia speciosa

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Luís M. M. Vieira (Autor) ICBAS; Anake Kijjoa (Autor) ICBAS; Rujida Wilairat (Autor) Outra; Maria São José Nascimento (Autor) FFUP; Luis Gales (Autor) ICBAS; Ana Margarida Damas (Autor) ICBAS; Artur M. S. Silva (Autor) Outra; Ing-On Mondranondra (Autor) Outra; Werner Herz (Autor) Outra

Revista

Título: Journal of Natural Products

Vol. 67 Nº 12

Páginas: 2043-2047

ISSN: 0163-3864

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 13 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências exactas e naturais

Outras Informações

ID Authenticus: P-000-7J6

DOI: 10.1021/np049773h

Abstract (EN): A new friedolanostane, 7, and three triterpenes, 8, 9a, and 10, possessing the new 11(10→8)-abeolanostane carbon skeleton were isolated from the bark of Garcinia speciosa. Structures were elucidated by spectroscopic and spectrometric studies and the structure of 8 by X-ray crystallographic analysis, thus forcing structure revision of a triterpene from the same source previously assumed to be a friedolanostane. These and several friedo- and lanostanes earlier isolated from the same source were evaluated for cytotoxicity against three human cell lines. Most were moderately active, with three friedolanostanes effective in inducing apoptosis in the MCF-7 cell line.

Idioma: Inglês

Tipo (Avaliação Docente): Científica