Antihyperglycemic Potential of Incretins Orally Delivered via Nano and Microsystems and Subsequent Glucoregulatory Effects

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Francisca Araujo (Autor) Outra; Neha Shrestha (Autor) Outra; Pedro L Granja (Autor) FEUP; Jouni Hirvonen (Autor) Outra; Helder A Santos (Autor) Outra; Bruno Sarmento (Autor) Outra

Revista

Título: Current Pharmaceutical Biotechnology

Vol. 15

Páginas: 609-619

ISSN: 1389-2010

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-009-V6A

Abstract (EN): Type 2 diabetes mellitus (T2DM) is mainly associated with impaired insulin secretion by the pancreatic beta-cells, insulin resistance and elevated hepatic gluconeogenesis. Incretin based treatments for T2DM are now widely investigated and used. The incretin based therapies mainly include incretin hormones which are glucose-dependent insulinotropic peptides (GIP) and glucagon like peptide-1 (GLP-1) released from the endocrinal cells in the small intestine in response to food intake. The main function of GLP-1 is to induce insulin secretion and suppress glucagon secretion. This review describes the different formulation approaches for oral delivery of incretins and the limitations associated with this route of administration. We highlight the use of micro and nanosystems to efficiently deliver the incretins orally. Furthermore, we present several examples of the significant potential of these systems in pharmaceutical applications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11