Injectable Biodegradable Polycaprolactone-Sebacic Acid Gels for Bone Tissue Engineering

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Christiane L Salgado (Autor) Outra; Elisabete M S Sanchez (Autor) Outra; Cecilia A C Zavaglia (Autor) Outra; Ana Beatriz Almeida (Autor) Outra; Pedro L Granja (Autor) FEUP

Revista

Título: Tissue Engineering - Part A

Vol. 18

Páginas: 137-146

ISSN: 1937-3341

Editora: Mary Ann Liebert

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 7 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

Outras Informações

ID Authenticus: P-002-H8G

DOI: 10.1089/ten.tea.2011.0294

Abstract (EN): Tissue engineering constitutes a promising alternative technology to transplantation medicine by creating viable substitutes for failing tissues or organs. The ability to manipulate and reconstitute tissue function has tremendous clinical implications and will most likely play a key role in cell and gene therapies in the coming years. In the present work, a novel injectable and biodegradable biomaterial is reported that could be injected on the human body with a surgical syringe. The material prepared is a blend of polycaprolactone (PCL), a biodegradable and elastic biomedical polymer, and sebacic acid, a natural polymer part of castor oil with low molecular weight to accelerate the slow degradation rate of PCL. The biocompatibility of the blend was evaluated in vitro and its in vivo behavior was also assessed through subcutaneous and bone implantation in rats to evaluate its tissue-forming ability and degradation rate. The results allowed the conclusion that the gel is biocompatible, promotes the differentiation of mesenchymal stem cells, and presents an adequate degradation rate for use in bone tissue engineering. In vivo the gel blends promoted tissue regeneration and adverse reactions were not observed on subcutaneous and bone implants.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10