Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Juliana Garcia (Autor) Outra; Vera M Costa (Autor) Outra; Ana Elisa Costa (Autor) Outra; Sergio Andrade (Autor) Outra; Ana Cristina Carneiro (Autor) Outra; Filipe Conceicao (Autor) Outra; Jose Artur Paiva (Autor) Outra; de Pinho, PG (Autor) FFUP; Paula Baptista (Autor) Outra; Maria de Lourdes Bastos (Autor) FFUP; Felix Carvalho (Autor) FFUP

Revista

Título: Toxicon

Vol. 103

Páginas: 55-59

ISSN: 0041-0101

Editora: Elsevier

Indexação

ISI Web of Knowledge - 9 Citações

Scopus - 15 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-00G-CN4

DOI: 10.1016/j.toxicon.2015.06.012

Abstract (EN): Mushroom poisonings occur when ingestion of wild mushrooms containing toxins takes place, placing the consumers at life-threatening risk. In the present case report, an unusual multiple poisoning with isoxazoles- and amatoxins-containing mushrooms in a context of altered mental state and poorly controlled hypertension is presented. A 68-year-old female was presented to Sao Joao hospital (Portugal) with complaints of extreme dizziness, hallucinations, vertigo and imbalance, 3 h after consuming a stew of wild mushrooms. The first observations revealed altered mental state and elevated blood pressure. The examination of cooked mushroom fragments allowed a preliminary identification of Amanita pantherina. Gas chromatography-mass spectrometry (GC-MS) showed the presence of muscimol in urine. Moreover, through high-performance liquid chromatography-ultraviolet detection (HPLC-UV) analysis of the gastric juice, the presence of alpha-amanitin was found, showing that amatoxins-containing mushrooms were also included in the stew. After 4 days of supportive treatment, activated charcoal, silybin and N-acetylcysteine, the patient recovered being discharged 10 days post-ingestion with no organ complications. The prompt and appropriate therapy protocol for life-threatening amatoxins toxicity probably saved the patient's life as oral absorption was decreased and also supportive care was immediately started.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5