Copper(II) increases bile acid binding to asparagine

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

de Castro, B (Autor) FCUP; Lima, JLFC (Autor) FFUP; Mayer, IH (Autor) Outra; Reis, S (Autor) FFUP

Revista

Título: Journal of Pharmaceutical and Biomedical Analysis

Vol. 16

Páginas: 771-776

ISSN: 0731-7085

Editora: Elsevier

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-001-9CQ

DOI: 10.1016/s0731-7085(97)00109-x

Abstract (EN): Interactions of two bile acids (cholic and glycocholic acids) with asparagine have been studied by potentiometry in aqueous solutions under conditions similar to those observed in biological fluids (37 degrees C and I = 0.15 M NaCl), and in the absence and presence of copper(II). To characterize the equilibria for the systems copper(II)/bile acid/asparagine, specifically to assess cooperative binding between bile acids and asparagine, the acidity constant of asparagine and formation constants for copper(ZI)/bile acid and copper(II)/asparagine were also obtained under the same conditions. The results obtained suggest cooperativity in the binding of bile acid to asparagine in the presence of copper(II). (C) 1998 Elsevier Science B.V.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6