Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Jaleco, AC (Autor) Outra; Neves, H (Autor) Outra; Hooijberg, E (Autor) Outra; Gameiro, P (Autor) Outra; Clode, N (Autor) Outra; Haury, M (Autor) Outra; Henrique, D (Autor) Outra; Parreira, L (Autor) Outra

Revista

Título: Journal of Experimental Medicine

Vol. 194

Páginas: 991-1001

ISSN: 0022-1007

Editora: Rockefeller University Press

Indexação

ISI Web of Knowledge - 241 Citações

Scopus - 260 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-000-T5H

DOI: 10.1084/jem.194.7.991

Abstract (EN): Notch signaling is known to differentially affect the development of lymphoid B and T cell lineages, but it remains unclear whether such effects are specifically dependent on distinct Notch ligands. Using a cell coculture assay we observed that the Notch ligand Delta-1 completely inhibits the differentiation of human hematopoietic progenitors into the B cell lineage while promoting the emergence of cells with a phenotype of T cell/natural killer (NK) precursors. In contrast, Jagged-1 did not disturb either B or T cell/NK development. Furthermore, cells cultured in the presence of either Delta-1 or Jagged-1 can acquire a phenotype of NK cells, and Delta-1, but not Jagged-1, permits the emergence of a de novo cell population coexpressing CD4 and CD8. Our results thus indicate that distinct Notch ligands can mediate differential effects of Notch signaling and provide a useful system to further address cell-fate decision processes in lymphopoiesis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11