PRIMARY LIVER-CANCER IN GENETIC HEMOCHROMATOSIS - A CLINICAL, PATHOLOGICAL, AND PATHOGENETIC STUDY OF 54 CASES

• Tipo: Artigo em Revista Científica Internacional
• Data: 1993

Autores

DEUGNIER, YM (Autor) Outra; GUYADER, D (Autor) Outra; CRANTOCK, L (Autor) Outra; LOPEZ, JM (Autor) FMUP; TURLIN, B (Autor) Outra; YAOUANQ, J (Autor) Outra; JOUANOLLE, H (Autor) Outra; CAMPION, JP (Autor) Outra; LAUNOIS, B (Autor) Outra; HALLIDAY, JW (Autor) Outra; POWELL, LW (Autor) Outra; BRISSOT, P (Autor) Outra

Revista

Título: Gastroenterology

Vol. 104

Páginas: 228-234

ISSN: 0016-5085

Editora: Elsevier

Indexação

ISI Web of Knowledge - 155 Citações

Scopus - 201 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-001-NK6

Abstract (EN): Background: Although liver cancer arises frequently in the course of genetic hemochromatosis (GH), it has not been previously studied in a large series of patients with well-defined GH. Methods: The bioclinical and pathological data from 1 cholangiocarcinoma and 53 hepatocellular carcinomas (HCCs) complicating GH in 32 untreated and 22 de-ironed patients are reported. Results: This study (1) adds three new well-documented cases of HCC in noncirrhotic but only fibrotic hemochromatotic liver, (2) shows the high prevalence (83%) of proliferative and often dysplastic (70%) iron-free foci in the nontumorous liver of untreated patients, and (3) emphasizes the significant increase of cirrhosis (81% vs. 28%) and of associated noniron-related risk factors, mainly chronic alcoholism (48% vs. 25%) and tobacco smoking (50% vs. 18%) in patients with HCC compared with matched hemochromatotic patients without HCC. Conclusions: These data (1) suggest that iron-free foci may be markers of an early stage of HCC in GH and (2) supply the basis for defining a cost-effective policy for the screening of HCC in GH patients. © 1993 by the American Gastroenterological Association.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7