The roles of cells and cytokines in the pathogenesis of psoriasis

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Susana Coimbra (Autor) Outra; Americo Figueiredo (Autor) Outra; Elisabeth Castro (Autor) Outra; Petronila Rocha Pereira (Autor) Outra; Alice Santos Silva (Autor) FFUP

Revista

Título: International Journal of Dermatology

Vol. 51

Páginas: 389-398

ISSN: 0011-9059

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 78 Citações

Scopus - 95 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-002-BSX

DOI: 10.1111/j.1365-4632.2011.05154.x

Abstract (EN): Psoriasis is considered an immune chronic disease in which T cells are accepted as important. Nowadays, it is believed that psoriasis is most likely a T helper (Th)1/Th17 induced inflammatory disease. However, some other cells, such as endothelial cells, dendritic cells, monocytic cells, neutrophils, keratinocytes, and several cytokines, appear to have, at different stages of the disease, an important role in its pathogenesis. For instance, the response to psoriasis therapy is dependent not only on the inactivation of Th1 and Th17 immune responses but also on the inactivation of dendritic cell products. Moreover, interleukin (IL)-23 deregulation appears to be an independent factor in the pathogenesis of psoriasis. Indeed, currently, the IL-23/Th17 axis is believed to be crucial in psoriasis pathogenesis, and its inhibition appears to be important for therapeutic achievement. This review presents the roles and interactions of cells and cytokines that are related to psoriasis pathogenesis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10