Principal Determinants of the Length of Remission of Psoriasis Vulgaris After Topical, NB-UVB, and PUVA Therapy A Follow-Up Study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Susana Coimbra (Autor) Outra; Hugo Oliveira (Autor) Outra; Luis Belo (Autor) FFUP; Americo Figueiredo (Autor) Outra; Petronila Rocha Pereira (Autor) Outra; Alice Santos Silva (Autor) FFUP

Revista

Título: American Journal of Clinical Dermatology

Vol. 14

Páginas: 49-53

ISSN: 1175-0561

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 11 Citações

Scopus - 16 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-005-319

DOI: 10.1007/s40257-012-0002-8

Abstract (EN): Background Periods of remission and of exacerbation of psoriatic lesions are common in psoriasis. We recently reported C-reactive protein (CRP) as a marker of psoriasis severity and that some patients still presented with a residual inflammation after treatment. We wondered if this residual inflammation could underlie an earlier exacerbation of psoriasis. Objective The purpose of our study was to evaluate if there is a relationship between CRP levels, Psoriasis Area and Severity Index (PASI), and body mass index (BMI), at the end of psoriasis treatment, with the length of psoriasis remission. Methods We followed 46 patients studied at the end of treatment, to record the length of remission; 9 of the patients were treated with topical agents, 17 with narrow-band UVB (NB-UVB), and 20 with psoralen plus UVA (PUVA). Results We found that the length of remission correlated with the values for PASI and CRP at the end of therapy. By performing a multiple linear regression analysis, CRP, PASI, and BMI were each significantly associated with length of remission. Patients with residual inflammation at the end of treatment presented with a significantly shorter length of remission. When considering patients grouped according to the used therapies, CRP and PASI also emerged as potential determinants of length of remission, especially in the case of patients treated with NB-UVB and topical therapy. Conclusion Our data suggest that CRP and PASI are important determinants of length of psoriasis remission for patients treated with phototherapy or topical therapy. Further studies with larger groups of patients are warranted to test this hypothesis. Moreover, we propose that, by the end of the treatment, the evaluation of CRP and PASI could be important to decide, when possible, if the treatment should be continued to achieve lower CRP values and longer periods of remission.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5