C-reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Coimbra, S (Autor) Outra; Oliveira, H (Autor) Outra; Reis, F (Autor) Outra; Belo, L (Autor) FFUP; Rocha, S (Autor) FFUP; Quintanilha, A (Autor) ICBAS; Figueiredo, A (Autor) Outra; Teixeira, F (Autor) Outra; Castro, E (Autor) Outra; Rocha Pereira, P (Autor) Outra; Santos Silva, A (Autor) FFUP

Revista

Título: Journal of the European Academy of Dermatology and Venereology

Vol. 24 Nº 10

Páginas: 789-796

ISSN: 0926-9959

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 81 Citações

Scopus - 103 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-003-5CV

DOI: 10.1111/j.1468-3083.2009.03527.x

Abstract (EN): Background Psoriasis vulgaris is a chronic recurrent inflammatory skin disease and psoriatic lesions have shown leucocyte infiltration. Objectives We aimed to study C-reactive protein (CRP) and leucocyte activation markers/inhibitors as potential monitors of psoriasis vulgaris. Methods A cross-sectional (n = 73) and a longitudinal study (before, at 3, 6 and 12 weeks of therapy; n = 47) was performed; 10 patients started topical treatment, 17 narrow-band ultraviolet light B (NBUVB) and 20 psolaren associated to UVA (PUVA); psoriasis severity was defined by Psoriasis Area and Severity Index (PASI). Results Compared with control (n = 38), we found higher CRP levels, total leukocyte/neutrophil count, elastase, lactoferrin and alpha 1-antitrypsin. Increasing PASI was linked to increasing CRP and a trend to higher elastase and lactoferrin, suggesting that worsening enhances inflammatory response with neutrophil activation. CRP correlated with PASI, total leucocytes, neutrophils, elastase, lactoferrin and alpha 1-antitrypsin. NBUVB and PUVA presented similar effects. Conclusion We propose CRP as a useful marker of psoriasis severity that could be used to monitor psoriasis and its treatment, and, together with PASI and elastase, could also be used as a global index of severity.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8