Molecular Recognition Force Spectroscopy: A New Tool to Tailor Targeted Nanoparticles

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Hugo Oliveira (Autor) Outra; Martina Rangl (Autor) Outra; Andreas Ebner (Autor) Outra; Barbara Mayer (Autor) Outra; Peter Hinterdorfer (Autor) Outra; Ana P Pego (Autor) FEUP

Revista

Título: Small

Vol. 7

Páginas: 1236-1241

ISSN: 1613-6810

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 12 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia dos materiais

Outras Informações

ID Authenticus: P-002-RH6

DOI: 10.1002/smll.201002074

Abstract (EN): The density of targeting moieties in a nanoparticle-based gene-delivery system has been shown to play a fundamental role in its vectoring performance. Here, molecular recognition force spectroscopy is proposed as a novel screening tool to optimize the density of targeting moieties of functionalized nanoparticles towards attaining cell-specific interaction. By tailoring the nanoparticle formulation, the unbinding event probability between nanoparticles tethered to an atomic force microscopy tip and neuronal cells is directly correlated to the nanoparticle gene-vectoring capacity. Additionally, new insights into protein-receptor interaction are revealed. This novel approach opens new avenues in the field of nanomedicine.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6