Clinical Predictors of Colectomy in Patients with Ulcerative Colitis: Systematic Review and Meta-analysis of Cohort Studies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Claudia Camila Dias (Autor) Outra; Pedro Pereira Rodrigues (Autor) FMUP; Altamiro da Costa Pereira (Autor) Outra; Fernando Magro (Autor) Outra

Revista

Título: Journal of Crohn's and Colitis

Vol. 9

Páginas: 156-163

ISSN: 1873-9946

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 49 Citações

Scopus - 53 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-00G-451

DOI: 10.1093/ecco-jcc/jju016

Abstract (EN): Introduction: Colectomy is a major event that may significantly affect the outcome of ulcerative colitis (UC) in terms of both quality of life and mortality. This paper aims to identify clinical prognostic factors that may be significantly associated with this event. Methods: PubMed, ISI Web of Knowledge and Scopus were searched to identify studies investigating the association between clinical factors in adult patients with UC and studied events. The clinical factors evaluated in this meta-analysis were gender, smoking habits, disease extent, use of corticosteroids, and episodes of hospitalization. Results: Of the 3753 initially selected papers, 20 were included. The analysis showed a significantly lower risk of colectomy for female patients (odds ratio [OR] 0.78 [95% CI 0.68, 0.90]) and for smoking patients (OR 0.55 [0.33, 0.91]), and a higher risk for patients with extensive disease (OR 3.68 [2.39, 5.69]), for patients who took corticosteroids at least once (OR 2.10 [1.05, 4.22]), and for patients who were hospitalized (OR 4.13 [3.23, 5.27]). Conclusion: Gender, smoking habits, disease extent, need for corticosteroids, and hospitalization were all significantly associated with UC prognosis. These results may clarify the relative influences of these and other prognostic factors in the natural course of the disease and therefore help improve the management approach, thus improving the follow-up of patients.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8