Acetylation genotype and the genetic susceptibility to prostate cancer in a southern European population

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Costa, I (Autor) Outra; Pinto, D (Autor) Outra; Morais, A (Autor) Outra; Vasconcelos, A (Autor) Outra; Oliveira, J (Autor) Outra; Lopes, C (Autor) ICBAS; Medeiros, R (Autor) ICBAS

Revista

Título: Prostate

Vol. 64

Páginas: 246-252

ISSN: 0270-4137

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 30 Citações

Scopus - 29 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-000-28S

DOI: 10.1002/pros.20241

Abstract (EN): BACKGROUND. Epidemiologic studies have suggested that environmental factors and diet are important risk factors in the pathogenesis of prostate cancer. The N-acetyltransferases (NAT) are important enzymes in activation and inactivation of various carcinogens, including those found in well-cooked meat and cigarette smoke. METHODS. We analyzed DNA samples from 146 prostate cancer patients and 174 healthy men. We used PCR-RFLP method to analyze NAT1 and NAT2 polymorphisms. RESULTS. We did not find statistically significant differences in NATI genotypes frequencies between prostate cancer patients and control group. We observed an association of the slow acetylator genotype, NAT2*6/NAT2*6 with prostate cancer protection (P = 0.017; OR = 0,31, 95%(CI 0.11-0.84). Multivariate logistic regression analysis confirmed this association (0.030; OR = 0.32,95% CI 0.12-0.89). CONCLUSIONS. Our results indicate a role of NAT2 polymorphisms in the carcinogenic pathway of prostate cancer, specifically in a population of Southern Europe. (c) 2005 Wiley-Liss, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7