Genetic Risk Markers for Nasopharyngeal Carcinoma in Portugal: Tumor Necrosis Factor Alpha -308G > A Polymorphism

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Hugo Sousa (Autor) Outra; Eduardo Breda (Autor) Outra; Alexandra M Santos (Autor) Outra; Raquel Catarino (Autor) Outra; Daniela Pinto (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: DNA and Cell Biology

Vol. 30

Páginas: 99-103

ISSN: 1044-5498

Editora: Mary Ann Liebert

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 25 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-002-VJH

DOI: 10.1089/dna.2010.1086

Abstract (EN): The tumor necrosis factor-alpha (TNF-alpha) is a strong proinflammatory cytokine produced by the activated macrophages in the immune response to viral infections. A common polymorphism on the promoter region of TNFA gene (-308G>A) has been associated with different susceptibilities to the development of several diseases including viral-associated neoplasias. Data suggest that the A allele has been associated with higher levels of TNF-a and, therefore, leads to increased risk of cancer development. We have performed a case-control study considering the role of the -308G>A polymorphism in 750 individuals from the northern region of Portugal, including 123 patients with nasopharyngeal carcinoma (NPC) and 627 healthy individuals. Our study revealed an increased frequency of the -308A TNFA allele in patients with NPC. The statistical analysis for recessive model revealed that -308AA genotype is associated with increased risk for the development of NPC (odds ratio=2.46; 95% confidence interval, 0.98-6.17; p=0.047); moreover, this effect was stronger in undifferentiated types, which are virtually 100% caused by the Epstein-Barr virus (odds ratio=2.75; 95% confidence interval, 1.09-6.90; p=0.025). These results reveal that in our population 308 TNFA AA genotype can represent a risk marker for NPC development and contributes for the definition of genetic susceptibility profiles for individuals at risk of development of a viral infection and associated neoplasia.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5