Localization of Candidate Genes in a Region of High Frequency of Microvariant Alleles for Prostate Cancer Susceptibility: The Chromosome Region Yp11.2 Genetic Variation

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Raquel Carvalho (Autor) Outra; Maria Fatima Pinheiro (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: DNA and Cell Biology

Vol. 29

Páginas: 3-7

ISSN: 1044-5498

Editora: Mary Ann Liebert

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 5 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-003-AKM

DOI: 10.1089/dna.2009.0905

Abstract (EN): The Y chromosome has been suggested to play a role in prostate cancer (PCa) because the loss of this chromosome is the most common aberration in PCa. Study of short tandem repeats (STRs) could provide a means to rapidly scan genomes at known or unknown predisposing loci for some diseases. DNA samples from 281 patients with PCa at the Portuguese Institute of Oncology, Porto, Portugal, and a population control of 175 healthy controls were analyzed for region Yp11.2 using AmpFlSTR (R) Y-Filer (TM) kit (Applied Biosystems). The results demonstrated that microvariant alleles of DYS458 are overrepresented (p = 0.026). We found that allele 12 of DYS393 and allele 19 of DYS458 could have a protective effect (p = 0.0051; odds ratio [OR] = 0.48; 95% confidence interval [95% CI] 0.27-0.38; and p = 0.0272; OR = 0.47; 95% CI 0.22-0.98). On the other hand, patients carrying allele 13 of DYS393 presented an increased risk to PCa (p = 0.015; OR = 1.97; 95% CI 1.26-3.07). These results are in concordance with the involvement of Y chromosome in PCa development. STR allele studies may add further information from the definition of a genetic profile of PCa resistance or susceptibility. As TSPY is located at region Yp11.2, this gene could play an essential role in PCa development.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5