TP73 alterations in cervical carcinoma

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Craveiro, R (Autor) Outra; Costa, S (Autor) Outra; Pinto, D (Autor) Outra; Salgado, L (Autor) Outra; Carvalho, L (Autor) Outra; Castro, C (Autor) Outra; Bravo, I (Autor) Outra; Lopes, C (Autor) ICBAS; Silva, I (Autor) Outra; Medeiros, R (Autor) ICBAS

Revista

Título: Cancer Genetics and Cytogenetics

Vol. 150

Páginas: 116-121

ISSN: 0165-4608

Editora: Elsevier B.V.

Indexação

ISI Web of Knowledge - 28 Citações

Scopus - 27 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-000-AST

DOI: 10.1016/j.cancergencyto.2003.08.020

Abstract (EN): Infection with human papillomaviruses (HPV) is essential in the carcinogenesis of the uterine cervix. However, a complex interrelation between viral and cellular genes is necessary for cell-cycle control deregulation and development and progression of cervical cancer induction. The TP73 gene is localized in I p36.3 band, which is often deleted by loss of heterozygosity (LOH) in human cancers. We analyzed the p73 cytosine thymine polymorphism and LOH in this locus by polymerase chain reaction restriction fragment length polymorphism in 134 DNA samples from biopsies of 67 primary untreated invasive cervix tumors and the corresponding peripheral blood. Genotype frequencies of 56.7% for homozygous genotype GC/GC and 43.3% for heterozygous genotype GC/AT were found. The presence of the GUAT genotype in tumors was associated with lower age at menarche (P = 0.039) and high parity (P = 0.015). In 20.0% of DNA tumor samples, the AT allele was lost compared with their DNA normal blood pairs. The AT allele was conserved in women with high parity. This was not the case in the group with low parity, with 33.3% of patients showing loss of the AT allele in tumor DNA (P = 0.041). These results suggest that TP73 genetic alterations may contribute to the genesis and/or progression of cervical carcinoma in an HPV-infected transformation zone under prolonged exposure to events related to pregnancy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6