Oncogenic virus-associated neoplasia: A role for cyclin D1 genotypes influencing the age of onset of disease?

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Catarino, R (Autor) Outra; Pereira, D (Autor) Outra; Breda, E (Autor) Outra; Coelho, A (Autor) Outra; Matos, A (Autor) Outra; Lopes, C (Autor) ICBAS; Medeiros, R (Autor) ICBAS

Revista

Título: Biochemical and Biophysical Research Communications

Vol. 370

Páginas: 118-122

ISSN: 0006-291X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 18 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

Outras Informações

ID Authenticus: P-003-ZBY

DOI: 10.1016/j.bbrc.2008.03.039

Abstract (EN): Cyclin D1 (CCND1) is a key regulatory protein at the G1/S checkpoint of the cell cycle. The purpose of our study was to assess the role of CCND1 genotypes influencing the age of onset of oncogenic virus-associated neoplasia. We conducted a hospital-based case-control study of 581 individuals, including 247 controls and 334 cases (108 nasopharyngeal and 226 cervical cancer cases). The polymorphism analysis was performed in blood samples by PCR-RFLP methodology. Age-adjusted logistic regression analysis indicates that individuals carrying two G-alleles have an increased genetic susceptibility for the development of oncogenic virus-associated cancers (aOR = 2.02, 95% CI 1.30-3.14, P = 0.002). Moreover, our results indicate that the waiting time for onset of oncogenic virus-associated neoplasia in patients homozygous (GG) for CCND1 genotypes (52 years) was 12 years earlier in comparison with patients carrying AG or AA genotypes (60 years) (log-rank test: P = 0.0003). Our results may be important in contributing to a more extensive knowledge of the mechanisms involved in oncogenic virus-associated carcinogenesis, as CCND1 may be an important target for the development of new strategies for cancer treatment and prevention.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5