Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery

• Tipo: Artigo em Revista Científica Internacional
• Data: 2004

Autores

Souto, EB (Autor) Outra; Wissing, SA (Autor) Outra; Barbosa, CM (Autor) FFUP; Muller, RH (Autor) Outra

Revista

Título: International Journal of Pharmaceutics

Vol. 278

Páginas: 71-77

ISSN: 0378-5173

Editora: Elsevier

Indexação

ISI Web of Knowledge - 434 Citações

Scopus - 539 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-000-9XR

DOI: 10.1016/j.ijpharm.2004.02.032

Abstract (EN): Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many Substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles, as well as the entrapment efficiency of this lipophilic drug and its in vitro release profile. The particle size was analyzed by PCS and LD showing that the particles remained in their colloidal state during 3 months of storage at 4, 20 and 40degreesC. For all tested formulations the entrapment efficiency was higher than 50%. The obtained results also demonstrate the use of these lipid nanoparticles as modified release formulations for lipophilic drugs over a period of 10 h.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7